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Incident

Sepsis model switched off after COVID-19 changed the patient mix

Weeks after its first COVID-19 admissions, the University of Michigan paused Epic sepsis alerts because dataset shift produced spurious alerting; its clinical AI committee decommissioned the model.

Sources checked when written 26 September 2026

TierThe hospital deactivated the sepsis model after its alerts became spurious. How tiers are assigned.

What happened

Finlayson and colleagues report that the University of Michigan Hospital deactivated the Epic sepsis-alerting model in April 2020 because changes in patient characteristics during the pandemic altered the relationship between fever and bacterial sepsis, producing spurious alerts; the hospital's clinical AI governing committee decommissioned its use. A companion study of 24 US hospitals found the share of patients generating sepsis alerts per day rose from 9% to 21% in the three weeks after each hospital's first COVID-19 case, while census fell. Michigan paused alerts 3 to 4 weeks after its first COVID-19 hospitalization, following nursing reports of overalerting.[1,2]

Documented harm

None documented.

What it teaches

Sources

  1. The Clinician and Dataset Shift in Artificial Intelligence. New England Journal of Medicine (Finlayson SG, Subbaswamy A, Singh K, et al.), 15 July 2021. Primary Peer-reviewed · link checked 2026-09-26
  2. Quantification of Sepsis Model Alerts in 24 US Hospitals Before and During the COVID-19 Pandemic. JAMA Network Open (Wong A, Cao J, Lyons PG, et al.), 1 November 2021. Primary Peer-reviewed · link checked 2026-09-26

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